Top Stocks today: Tilray, Alibaba gain; Novo Nordisk slips

Monday, Sept 29, 2025

The market closed on a bullish note today despite the looming threat of a government shutdown.

  • The market opened strong, and the government shutdown looms large.
  • Stocks of the pharmaceutical company Tilray soar after President Trump posts a video.
  • Alibaba promises increased investment in AI infrastructure, and its stock rises.

The S&P 500 was up 0.3%, rallying on a surge from Robinhood and a turnaround from Nvidia. 

The Nasdaq Composite and Dow Jones Industrial Average closed 0.5% and 0.2% higher, respectively. 

The Russell 2000 fell during early trading hours but closed 0.04% higher.

Alibaba, which has been gaining traction in AI demands, was up 4.7%, while Tilray, a pharmaceutical company, soared 60.9% today. 

Novo Nordisk, maker of weight loss drug Ozempic, slipped 0.2% after an analyst downgrade.

Alibaba stock up 112% year-to-date

Getty/TheStreet

The US stock market is awaiting the impending impact of a probable government shutdown, effective October 1, if the ongoing congressional negotiations do not result in a settlement.

Democrats are demanding an extension of the healthcare subsidy, and congressional action will only occur if the Democrats and Republicans can negotiate a deal.

A likely shutdown may result in significant layoffs in the federal government.

Here are the stocks that made the biggest market moves today

Five S&P 500 stocks making big moves today are:

  • Robinhood Markets Inc HOOD: +12.3%
  • Western Digital Corp WDC: +9.2%
  • Coinbase Global Inc COIN: +6.8%
  • Applovin Corp APP: +6.3%
  • CSX Corp CSX: +5.4%

The worst-performing five S&P 500 stocks today are:

  • William-Sonoma Inc WSM: -4.7%
  • Vistra Corp : -4.5%
  • Carnival Corp CCL: -3.9%
  • Devon Energy Corp DVN: -3.9%
  • Campbell’s Co CPB: -3.8%

Stocks also worth noting include:

  • Wolfspeed : +1,726.5%
  • Baidu BIDU: +2.7%.
  • Electronic Arts EA: +4.5%
  • PayPal PYPL: +3.5%
  • Nvidia NVDA: +2.1%

Pro cannabis Trump stance sparks stock price

Cannabis industry stocks rose today after President Donald Trump posted a video on his Truth Social, which advocated cannabis as beneficial for elderly care, suggesting it be covered under Medicare.

More Health Care:

  • Americans’ health insurance bills could surge by 75% next year
  • Walmart forms bold new health care partnership for affordable medicine
  • 25% of Americans Are Burned Out Before 30

Tilray  (TLRY) , a global lifestyle and consumer packaged goods company with a significant cannabis segment, reacted optimistically to the probable legalization of cannabis at the federal level.

The company stock was up 60.9%, a 52-week high for this billion-dollar company. With a 39% year-to-date increase, investor sentiment remains optimistic about potential federal subsidies and subsequent expansion opportunities for Tilray.

The company is going through a financially challenging time, with its stock currently priced at $1.85. This surge appears temporary, as shares were trading lower after closing hours at last check.

Alibaba rides bullish analyst sentiment

There is a wave of investment in AI infrastructure, and Alibaba  (BABA) , a Chinese technology infrastructure and marketing platform company, is participating.

Related: Alibaba rides wave as China sharply expands AI spending

Its stock was up 4.7% today, a 52-week high for the commerce giant. This multi-billion-dollar company has reported a 112% year-to-date increase and is expected to continue rising, according to analyst reports.

Jefferies raised the firm’s price target to $230 from $178, estimating triple-digit growth for Alibaba’s cloud-related revenue.

Bank of America raised its price target to $195 from $168 after its annual Apsara Conference. The analysts believe that Alibaba is positioned as the world’s leading full-stack artificial intelligence services provider, as reported at TheFly.

At the annual conference, the firm announced that it would exceed its previously announced $53 billion investment to develop AI infrastructure over the next three years.

Related: Ozempic creator Novo Nordisk is selling its weight loss drugs for cheaper through this new partnership

The Ozempic manufacturer suffers after downgrade

Novo Nordisk  (NVO) , a Danish pharmaceutical giant, has been in the news for its role as the manufacturer of the weight loss drug Ozempic.

It reported a 0.2% loss at the close today after Morgan Stanley downgraded its price target to $47 from $59, with an Underweight rating, a downgrade from its earlier Equal Weight rating.

Stanley cited the lack of momentum in US prescriptions as the reason for its cautious outlook on the firm’s short-term growth profile, which led to the downgrade.

Related: Billionaire rings alarm with one-word AI warning

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